1. Skeletal Muscle as a Glucose Sink

• Muscles are the primary site for glucose disposal in the body, accounting for 70–80% of post eating glucose uptake.
• The more lean muscle mass you have, the more glucose transporters (GLUT4) are available to shuttle glucose out of the bloodstream and into muscle cells.
• This lowers circulating glucose and insulin levels, which is beneficial because:
  -As we know, many cancers are glucose hungry
  -High insulin and glucose levels can fuel cancer growth, especially in insulin-sensitive or glycolysis-driven tumours.
  

2. Cancer Metabolism and the Warburg Effect

• Most cancer cells rely on aerobic glycolysis for energy (even in the presence of oxygen), a phenomenon known as the Warburg effect.
• This metabolic shift makes cancer cells highly dependent on glucose.
• By increasing muscle mass, you can compete for glucose and potentially starve cancer cells of their preferred fuel source.

3. Lower Systemic Inflammation

• Muscle acts like an endocrine organ, releasing myokines during contraction that have anti-inflammatory and anti-tumor effects.
• More muscle → more myokine production → better modulation of chronic inflammation, which is a known cancer driver.

4. Improved Insulin Sensitivity and Metabolic Control

• Resistance training and increased muscle mass improve insulin sensitivity.
• This helps reduce hyperinsulinemia, which is linked to poor cancer outcomes some cancers
• Insulin can act as a growth factor for tumours, so keeping it in check is critical.
  
  

5. Prevention of Cachexia

• Muscle wasting (cachexia) is a common and deadly complication in advanced cancer.
• Maintaining or increasing muscle mass delays or prevents the onset of cachexia.
• This improves treatment tolerance, physical function, and survival.